Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 1414
interventional 883
Observational 461
Registry 70

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 241
Device 120
Procedure 106
Drug|placebo 99
Other 87
Behavioral 62
Drug|Procedure 21
Biological 20
Diagnostic Test 16
Biological|placebo 14
Device|Other 9
Drug|Other 9
Device|Drug 8
Device|Procedure 8
Other|Procedure 7
Behavioral|Other 6
Behavioral|Drug 4
Genetic 4
Device|Drug|Procedure 3
Dietary Supplement 3
Drug|placebo|Procedure 3
Biological|Other 2
Biological|Procedure 2
Device|Drug|placebo 2
Dietary Supplement|placebo 2
Drug|Genetic 2
Drug|Other|placebo 2
Drug|Other|Procedure 2
Other|placebo 2
Behavioral|Biological 1
Behavioral|Device 1
Behavioral|Diagnostic Test 1
Behavioral|Procedure 1
Biological|Device|Other|Procedure 1
Biological|Device|placebo 1
Biological|Drug 1
Biological|Drug|Procedure 1
Combination Product 1
Combination Product|Procedure 1
Device|Drug|Other 1
Diagnostic Test|Other 1
Dietary Supplement|Drug 1
Drug|Procedure|Radiation 1
placebo 1
Procedure|Radiation 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 134
NA 75
Canada 52
Italy 44
China 42
France 39
Germany 37
Korea, Republic of 34
Denmark 33
United Kingdom 28
Netherlands 25
Sweden 23
Norway 22
Spain 20
Brazil 18
Japan 14
Switzerland 14
Greece 13
Poland 9
Russian Federation 8
Iran, Islamic Republic of 7
Turkey 7
Austria 6
Israel 6
Taiwan 6
United States|Canada 6
Belgium 5
Finland 4
India 4
Singapore 4
Czech Republic 3
Czechia 3
Indonesia 3
Pakistan 3
Portugal 3
Slovenia 3
Austria|Germany 2
Croatia 2
Denmark|Iceland|Sweden 2
Egypt 2
France|Germany 2
Italy|Switzerland 2
Kazakhstan 2
Netherlands|Poland 2
Romania 2
Thailand 2
United States|Puerto Rico 2
Algeria|Australia|Austria|Canada|Denmark|France|Germany|Hungary|Italy|Netherlands|Spain|Sweden|United Kingdom 1
Argentina 1
Argentina|Australia|Brazil|Canada|China|Colombia|New Zealand|Peru|Russian Federation|Ukraine 1
Argentina|Brazil|Italy|Paraguay|Spain 1
Argentina|Canada|India 1
Australia 1
Australia|Bangladesh|Czechia|Denmark|Latvia|Norway|Sweden|United Kingdom 1
Australia|Canada|Chile|France|Mexico|Romania|Russian Federation|Serbia|Spain 1
Austria|Belgium|Brazil|Canada|Chile|France|Germany|Greece|Italy|Norway|Peru|Poland|Russian Federation|Serbia|Spain|United Kingdom 1
Austria|Belgium|Canada|Czech Republic|Finland|France|Germany|Hungary|Israel|Italy|Latvia|Lithuania|Netherlands|Poland|Portugal|Romania|Slovakia|Sweden|Turkey 1
Austria|Belgium|Czech Republic|Denmark|Germany|Lithuania|Netherlands|Poland|Romania|Sweden|Switzerland 1
Austria|Belgium|Hungary|Netherlands|Poland 1
Austria|Denmark|Slovenia|Sweden 1
Austria|Estonia|Hungary|Poland|Serbia|Slovenia|Sweden|United Kingdom 1
Austria|Germany|Hungary|Poland|United Kingdom 1
Austria|Germany|Italy 1
Austria|Germany|Switzerland 1
Belgium|Czechia|Luxembourg|Netherlands 1
Belgium|Finland|Netherlands|Switzerland|United Kingdom 1
Belgium|France 1
Belgium|France|Spain 1
Belgium|Germany|Netherlands 1
Belgium|Hungary|Poland 1
Belgium|Italy|Netherlands 1
Belgium|Switzerland 1
Belgium|United States|Argentina|Austria|Bulgaria|Canada|Czech Republic|Denmark|France|Germany|Israel|Netherlands|Poland|Romania|South Africa|Spain|Sweden|Switzerland|United Kingdom 1
Brazil|Czechia|Hungary|Israel|Netherlands|Poland|Russian Federation|Slovakia|Spain|United Kingdom 1
Brazil|Italy|Macedonia, The Former Yugoslav Republic of|Serbia|Spain 1
Bulgaria|United States|Argentina|Australia|Canada|Czechia|Denmark|France|Germany|Hungary|Italy|Korea, Republic of|Netherlands|Poland|Russian Federation|Spain|Sweden|Taiwan|United Kingdom 1
Canada|Chile|Spain 1
Canada|Croatia|Czech Republic|Germany|Hungary|India|Israel|Lebanon|Poland|Romania|Russian Federation|Slovakia|Slovenia|South Africa|Spain|Turkey|United Kingdom 1
Canada|Czech Republic|France|Germany|Greece|Hungary|Netherlands|Poland|Slovakia|Spain|United Kingdom 1
Canada|France 1
Canada|United States|Bangladesh|India|Iran, Islamic Republic of|Pakistan|Tunisia 1
Canada|United States|Netherlands|Poland 1
China|Hong Kong|Korea, Republic of 1
China|United Kingdom 1
Czechia|France|Germany|Hungary|Italy|Poland|Spain 1
Czechia|Germany|Hungary|Netherlands|Norway|Poland|Singapore|Sweden 1
Czechia|Germany|Israel|Italy|Spain 1
Czechia|Slovakia 1
Denmark|France|Germany|Netherlands 1
Denmark|France|Norway|Sweden 1
Denmark|Germany 1
Denmark|Netherlands|Spain|Switzerland 1
Denmark|Norway 1
Denmark|Spain 1
Denmark|Switzerland|United Kingdom 1
France|Italy|Poland 1
France|Spain 1
France|Switzerland 1
France|United Kingdom 1
Germany|Austria 1
Germany|Italy 1
Germany|Switzerland 1
Germany|United Kingdom 1
Germany|United States|Australia|Canada|Israel|Italy|Puerto Rico|United Kingdom 1
Greece|Hungary|India|Netherlands|Spain|Sweden|Thailand|Tunisia|Turkey|Ukraine|Germany|United States|Argentina|Australia|Belgium|Brazil|Bulgaria|Canada|Chile|China|Colombia|Croatia|Czech Republic|Denmark|Egypt|France|Israel|Japan|Korea, Republic of|Latvia|Lithuania|Malaysia|Mexico|Morocco|New Zealand|Philippines|Poland|Portugal|Romania|Russian Federation|Serbia|Slovakia|United Kingdom 1
Greece|United States|China|Argentina|Australia|Austria|Belgium|Brazil|Bulgaria|Canada|Colombia|Croatia|Czechia|Denmark|Finland|France|Germany|Hungary|India|Israel|Italy|Korea, Republic of|Mexico|Netherlands|Norway|Peru|Philippines|Poland|Portugal|Romania|Russian Federation|Singapore|Slovakia|South Africa|Spain|Sweden|Switzerland|Taiwan|Thailand|Turkey|United Kingdom 1
Ireland 1
Ireland|Netherlands 1
Italy|Netherlands 1
Italy|Netherlands|Spain 1
Italy|Poland|Spain 1
Italy|Spain 1
Japan|Poland|Portugal|Ukraine|United States|Argentina|Australia|Brazil|Bulgaria|Canada|China|Czechia|Denmark|Estonia|France|Germany|Greece|Hungary|Korea, Republic of|Latvia|Lithuania|Malaysia|Mexico|Netherlands|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Turkey|United Kingdom 1
Mauritius 1
Netherlands|Norway|Poland|Switzerland 1
Netherlands|Spain 1
New Zealand|Norway|Poland|United States|Australia|Belgium|Canada|Czech Republic|Denmark|Finland|Germany|Hungary|Israel|Italy|Netherlands|Portugal|Spain|Sweden 1
Palestinian Territory, occupied 1
Poland|South Africa 1
Portugal|Spain 1
South Africa 1
Switzerland|Austria|Belgium|Czechia|Germany|Israel|Poland 1
United States|Argentina 1
United States|Argentina|Australia|Austria|Belarus|Belgium|Brazil|Bulgaria|Canada|Chile|China|Croatia|Denmark|Estonia|Finland|France|Germany|Greece|Hong Kong|Hungary|India|Ireland|Israel|Italy|Jordan|Korea, Republic of|Latvia|Lebanon|Lithuania|Malaysia|Mexico|Netherlands|Norway|Poland|Portugal|Romania|Russian Federation|Singapore|Slovakia|South Africa|Spain|Sweden|Switzerland|Thailand|Turkey|Ukraine|United Kingdom|Uruguay 1
United States|Argentina|Australia|Austria|Belarus|Belgium|Brazil|Bulgaria|Canada|Chile|Colombia|Croatia|Czech Republic|Egypt|Estonia|France|Germany|Greece|Hong Kong|Hungary|India|Indonesia|Israel|Italy|Jordan|Korea, Republic of|Latvia|Lebanon|Lithuania|Macedonia, The Former Yugoslav Republic of|Malaysia|Mexico|Montenegro|Netherlands|New Zealand|Norway|Panama|Peru|Poland|Portugal|Romania|Russian Federation|Serbia|Singapore|Slovakia|South Africa|Spain|Switzerland|Taiwan|Thailand|Tunisia|Turkey|Ukraine|United Kingdom|Vietnam 1
United States|Argentina|Australia|Austria|Belgium|Brazil|Canada|France|Germany|Hungary|Ireland|Israel|Italy|Mexico|Netherlands|Poland|Portugal|Puerto Rico|Russian Federation|South Africa|Spain|Sweden|Turkey|United Kingdom 1
United States|Argentina|Australia|Belgium|Brazil|Bulgaria|Canada|Chile|China|Colombia|Czech Republic|France|Germany|Hungary|Italy|Japan|Korea, Republic of|Netherlands|Norway|Peru|Philippines|Poland|Romania|Russian Federation|Slovakia|South Africa|Spain|Sweden|Turkey|Ukraine|United Kingdom 1
United States|Argentina|Australia|Belgium|Brazil|Canada|Chile|Czech Republic|France|India|Korea, Republic of|Mexico|Netherlands|Poland|Portugal|Russian Federation|Spain|Turkey 1
United States|Argentina|Belgium|Canada|Colombia|Czech Republic|Denmark|Germany|Hungary|India|Israel|Italy|Korea, Republic of|Netherlands|Norway|Poland|Russian Federation|Slovakia|Spain|Sweden|Turkey|United Kingdom|Venezuela 1
United States|Australia|Austria|Belgium|Brazil|Canada|China|Czech Republic|Finland|France|Germany|Greece|Hungary|Korea, Republic of|Macedonia, The Former Yugoslav Republic of|Netherlands|New Zealand|Serbia|Spain|United Kingdom 1
United States|Australia|Austria|Belgium|Canada|Czech Republic|Denmark|France|Germany|Italy|Netherlands|New Zealand|Poland|Portugal|Spain|Sweden|Switzerland 1
United States|Australia|Austria|Belgium|Czechia|Denmark|France|Germany|Hungary|Latvia|Netherlands|Poland|Slovakia|Spain 1
United States|Australia|Austria|Bulgaria|Canada|Czech Republic|Denmark|France|Germany|Hungary|Israel|Italy|Netherlands|Poland|Spain|United Kingdom 1
United States|Australia|Belgium|Canada|France|Germany|Israel|Poland|Spain 1
United States|Australia|Belgium|Denmark|France|Germany|Italy|Netherlands|New Zealand|Portugal|Spain|United Kingdom 1
United States|Australia|Belgium|France|Germany|India|Ireland|Italy|Netherlands|United Kingdom 1
United States|Australia|Canada|Germany|India|Netherlands|Poland|Spain|United Kingdom 1
United States|Australia|Czechia|Germany|Hungary|Latvia|Malaysia|New Zealand|Poland|Russian Federation|Singapore|Slovakia|Switzerland 1
United States|Austria|Germany|Netherlands|Poland|United Kingdom 1
United States|Belgium|Canada|Finland|France|Germany|Hungary|Italy|Norway|Saudi Arabia|Slovakia|South Africa|Spain|Sweden|United Kingdom 1
United States|Brazil|Canada 1
United States|Canada|Poland 1
United States|Canada|Puerto Rico 1
United States|Denmark|France|Germany|Hungary|Saudi Arabia|Slovakia 1
United States|France|Germany|United Kingdom 1
United States|Germany|Hungary|Israel|Netherlands 1
United States|Germany|Poland 1
United States|Greece|India 1
United States|Hungary|Poland|United Kingdom 1
United States|Israel 1
United States|Poland 1

Sites per Study

Site_count Study_Count
1 598
2 64
3 26
4 20
5 22
6 11
7 8
8 8
9 2
10 5
11 6
12 7
13 7
14 5
15 2
16 6
17 5
18 2
19 1
20 2
21 1
23 2
24 4
25 3
26 2
28 1
29 3
30 1
31 3
32 2
33 1
34 1
38 2
39 1
40 1
41 2
45 1
47 2
48 3
52 2
55 1
58 1
64 1
65 1
66 1
69 1
71 1
74 1
75 1
81 1
82 1
85 1
86 1
87 1
91 1
94 1
95 1
101 1
102 1
108 1
113 1
115 1
127 1
153 2
183 1
189 1
190 1
201 1
235 1
272 1
349 1
471 1
489 1
578 1
584 1
607 1
847 1

Phase

Phase Study_Count
N/A 348
Phase 4 201
Phase 3 151
Phase 2 100
Phase 2/Phase 3 32
Phase 1 27
Phase 1/Phase 2 21
Early Phase 1 3

Number of Arms

Number_of_Arms Count_of_Studies
1 85
2 561
3 93
4 38
5 5
6 4
NA 97

Number of Updates

Count of Versions Count of Studies
1 93
2 130
3 135
4 116
5 91
6 71
7 53
8 44
9 34
10 18
11 14
12 12
13 7
14 5
15 5
16 3
17 4
18 8
19 3
20 1
21 1
22 4
24 1
25 1
26 6
29 1
31 1
34 1
36 2
37 2
40 1
42 1
44 2
45 2
47 1
48 2
58 1
67 2
72 1
76 1
79 1
84 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 4730 790 5.987342
Contacts/Locations 2404 668 3.598802
Recruitment Status 1165 686 1.698251
Study Design 885 570 1.552632
None (earliest Version on record) 883 883 1.000000
Outcome Measures 690 401 1.720698
Sponsor/Collaborators 529 337 1.569733
Arms 492 336 1.464286
Interventions 492 336 1.464286
Eligibility 489 329 1.486322
Study Identification 473 287 1.648084
Study Description 455 312 1.458333
Oversight 347 277 1.252708
References 237 164 1.445122
Conditions 160 128 1.250000
More Information 127 41 3.097561
Results 85 85 1.000000
IPDSharing 74 71 1.042253
Results Submission Events 30 30 1.000000
Baseline Characteristics 25 23 1.086957
Documents 20 18 1.111111
Reported Adverse Events 17 16 1.062500
Participant Flow 14 12 1.166667

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 30.0000 2.000 6.0000 10.00 8.0000 20.0000 10.000 11.000
1st Qu. 95.0000 60.000 15.0000 13.75 50.0000 89.7500 120.000 80.000
Median 160.0000 142.000 27.0000 22.00 105.0000 110.5000 392.000 165.000
Mean 126.6667 1345.139 139.2593 54.50 201.2929 157.4375 2709.152 1077.265
3rd Qu. 175.0000 549.750 34.0000 92.50 221.5000 242.5000 2305.000 606.000
Max. 190.0000 50000.000 2800.0000 200.00 1267.0000 380.0000 39876.000 46000.000

Trial Group Type

group_type Group_Count
Experimental 677
Active Comparator 542
Placebo Comparator 190
No Intervention 144
Other 114
NA 97
Sham Comparator 20

Intervention Model

intervention_model Study_Count
Parallel Assignment 683
Single Group Assignment 115
NA 29
Crossover Assignment 27
Factorial Assignment 23
Sequential Assignment 6

Primary Purpose

primary_purpose Study_Count
Treatment 588
Prevention 112
Diagnostic 72
Health Services Research 29
Other 27
Supportive Care 23
NA 17
Basic Science 11
Screening 4

Observational Studies

Studies by Country

Country Study_Count
NA 115
United States 74
United Kingdom 31
China 30
Germany 20
France 18
Italy 15
Sweden 12
Canada 11
Austria 8
Israel 8
Korea, Republic of 8
Norway 8
Netherlands 7
Turkey 7
Denmark 6
Greece 6
Romania 6
Poland 5
Spain 5
Belgium 4
Brazil 4
Russian Federation 4
Switzerland 4
Taiwan 4
United States|Canada 3
Finland 2
Japan 2
Singapore 2
Argentina|Belgium|Brazil|Denmark|Finland|France|Germany|Greece|Italy|Luxembourg|Mexico|Netherlands|Norway|Poland|Romania|Slovenia|Spain|Turkey|United Kingdom|Venezuela 1
Argentina|Norway 1
Australia 1
Bangladesh|Brunei Darussalam|China|Egypt|India|Indonesia|Korea, Republic of|Malaysia|Pakistan|Philippines|Saudi Arabia|Singapore|South Africa|Taiwan|Thailand|Tunisia 1
Belgium|Bulgaria|Croatia|Czechia|Denmark|Finland|Germany|Greece|Hungary|Netherlands|Poland|Slovakia|Spain|Sweden|Switzerland|United Kingdom 1
Belgium|France 1
Brazil|Canada|China|Colombia|India|Malaysia|Spain 1
Brazil|Germany|Italy|United Kingdom 1
Bulgaria 1
Canada|Netherlands 1
China|India|Korea, Republic of|Singapore 1
Colombia 1
Costa Rica 1
Czech Republic 1
Czechia|Estonia|Germany|Hungary|Lithuania|Poland|Serbia|United Kingdom 1
Czechia|Italy|Poland|Spain|Switzerland 1
Egypt 1
Finland|Germany 1
Finland|Germany|Italy|Poland|Slovenia|Spain|Sweden 1
Haiti 1
Indonesia 1
Iran, Islamic Republic of 1
Japan|Korea, Republic of|Spain 1
Jordan 1
Pakistan 1
Poland|Slovenia 1
Saudi Arabia 1
Serbia 1
Spain|Sweden 1
Sweden|United Kingdom 1
United States|Australia|Brazil|Canada|China|Hong Kong|Italy|Malaysia|Poland|Russian Federation|Spain|United Kingdom 1
United States|Israel 1

Sites per Study

Site_count Study_Count
1 376
2 27
3 7
4 8
5 7
6 1
7 2
8 4
10 2
11 2
13 2
15 1
17 2
18 2
19 1
20 1
22 2
23 1
24 2
29 1
42 1
49 1
52 1
56 1
68 1
81 1
92 1
93 1
144 1
411 1

Number of Updates

Count of Versions Count of Studies
1 73
2 117
3 94
4 69
5 37
6 9
7 16
8 9
9 9
11 2
12 5
13 5
14 2
15 2
16 1
17 1
18 2
19 1
20 1
21 1
23 1
29 1
32 1
36 1
37 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 1395 388 3.595361
Contacts/Locations 504 231 2.181818
None (earliest Version on record) 461 461 1.000000
Recruitment Status 362 253 1.430830
Study Design 312 233 1.339056
Study Identification 196 136 1.441177
Sponsor/Collaborators 187 144 1.298611
Study Description 163 124 1.314516
Eligibility 160 131 1.221374
Outcome Measures 139 97 1.432990
References 106 52 2.038461
Oversight 82 79 1.037975
Groups 63 58 1.086207
Interventions 63 58 1.086207
Conditions 45 41 1.097561
IPDSharing 27 27 1.000000
More Information 17 8 2.125000
Results 15 15 1.000000
Baseline Characteristics 8 7 1.142857
Reported Adverse Events 7 5 1.400000
Results Submission Events 4 4 1.000000
Participant Flow 3 3 1.000000
Documents 2 2 1.000000

Enrollment Metrics

Measure Observational
Min 0.00
1st Qu 122.50
Median 555.00
Mean 35508.49
3rd Qu 2981.25
Max 2240000.00

Observation Model

observational_model Study_Count
Cohort 269
NA 79
Case-Only 36
Case Control 31
Case-Control 24
Other 14
Defined Population, Natural History 3
Ecologic or Community 2
Case-Crossover 1
Defined Population 1
Family-Based 1

Time Perspective

time_perspective Study_Count
Prospective 286
Retrospective 87
NA 56
Cross-Sectional 17
Other 11
Longitudinal, Prospective 3
Cross-Sectional, Prospective 1

Registries

Studies by Country

Country Study_Count
NA 14
United States 9
Germany 6
United Kingdom 6
Korea, Republic of 5
China 4
Brazil 3
Denmark 2
Egypt 2
France 2
Hungary 2
Italy 2
Netherlands 2
Sweden 2
Belgium|Netherlands 1
Colombia 1
Greece 1
Hong Kong|Korea, Republic of|Singapore|Taiwan|Thailand 1
Mexico 1
Russian Federation 1
Spain 1
Tunisia 1
Turkey 1

Sites per Study

Site_count Study_Count
1 53
2 2
3 2
4 2
5 1
9 2
10 1
14 2
16 2
37 1
55 1
90 1

Number of Updates

Count of Versions Count of Studies
1 18
2 10
3 17
4 7
5 3
6 3
7 5
8 1
9 2
11 2
28 1
59 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 249 52 4.788462
Contacts/Locations 111 33 3.363636
None (earliest Version on record) 70 70 1.000000
Recruitment Status 44 31 1.419355
Study Description 43 19 2.263158
Study Design 29 26 1.115385
Outcome Measures 22 15 1.466667
Eligibility 17 13 1.307692
Study Identification 14 9 1.555556
References 13 9 1.444444
Groups 12 9 1.333333
Interventions 12 9 1.333333
Sponsor/Collaborators 9 8 1.125000
IPDSharing 6 6 1.000000
Oversight 6 6 1.000000
Conditions 5 5 1.000000
Documents 3 3 1.000000
More Information 1 1 1.000000
Results 1 1 1.000000
Results Submission Events 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 11.00
1st Qu 533.00
Median 2000.00
Mean 73388.97
3rd Qu 7425.00
Max 2240000.00

Registry Model

observational_model Study_Count
Cohort 52
Case-Control 7
Case-Only 6
Other 3
Ecologic or Community 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 60
Other 4
Cross-Sectional 3
NA 3

Follow-up

target_duration Study_Count
1 Year 10
12 Months 9
5 Years 8
10 Years 7
2 Years 7
3 Years 5
6 Months 3
1 Day 2
1 Month 2
30 Days 2
1 Week 1
105 Months 1
13 Months 1
13 Years 1
15 Years 1
180 Days 1
24 Months 1
28 Days 1
4 Years 1
40 Days 1
5 Days 1
6 Years 1
7 Years 1
8 Years 1
88 Months 1